PHE’s Stevens and Chou Address Variations in Cost-Effectiveness Studies of PCSK-9 Inhibitors in New Commentary for Journal of Medical Economics
PHE’s Warren Stevens and Jacquelyn Chou, along with coauthor Peter Toth, examine the markedly different cost-effectiveness study results for PCSK-9 inhibitors in a new commentary in the Journal of Medical Economics. The authors attribute the differences primarily to variations in assumptions about the risk of cardiovascular disease events. They examine what types of data are most appropriate for assessment of baseline MACE risk and are likely to yield the most accurate estimate of cost-effectiveness of PCSK-9 inhibitors for real-world patients. They argue that a systematic approach to modeling cost- effectiveness is needed.
To read the complete commentary, please click here.
By: Jason Shafrin, PhD Sr. Director, Policy and Economics and Jacki Chou, MPL Senior Director, Policy and Economics The recent announcement that CVS Caremark will use value-based metrics to inform formulary design at first appears a step in the right direction. However, using value measurements from a single nongovernmental organization—the Institute for Clinical and Economic Review (ICER)—based on a limited picture of treatment value may be problematic. Using this single assessment of value in an effort solely to exclude drugs from a major insurance formulary is even more worrisome and fails to recognize the heterogeneity in patient clinical needs and preferences.